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Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

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The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Why do multiple sclerosis and migraine coexist?

Mehmet Hamamcı1, Ayse Yesim Göcmen2, Bahar Say3

  • 1Department of Neurology, Bozok University Medical School, Yozgat, Turkey.

Multiple Sclerosis and Related Disorders
|January 27, 2020
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Summary

Migraine and multiple sclerosis (MS) coexistence is linked to lower vitamin D and antioxidant levels, alongside higher oxidative stress markers in relapsing-remitting MS (RRMS) patients. Further research is needed to understand this relationship and its impact on treatment.

Keywords:
ComorbidityHigh-sensitivity C-reactive proteinOxidative stressRelationshipVitamin D

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Area of Science:

  • Neurology
  • Biochemistry
  • Immunology

Background:

  • Migraine is frequently observed in patients with multiple sclerosis (MS).
  • Understanding the underlying mechanisms of MS and migraine comorbidity is crucial for patient outcomes.
  • This study investigates biochemical markers associated with the coexistence of MS and migraine.

Purpose of the Study:

  • To investigate the relationship between vitamin D metabolism, oxidative stress markers, and the coexistence of relapsing-remitting multiple sclerosis (RRMS) and migraine.
  • To compare these markers in RRMS patients with and without migraine, and healthy controls.
  • To explore potential etiological factors and therapeutic targets for MS-migraine comorbidity.

Main Methods:

  • Cross-sectional study involving 50 RRMS patients with migraine, 50 RRMS patients without migraine, and 50 healthy volunteers.
  • Biochemical analysis of vitamin D, vitamin D-binding protein (VITDBP), vitamin D receptor (VITDR), high-sensitivity C-reactive protein (hs-CRP), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), total antioxidant status (TAS), total oxidant status (TOS), and Oxidative Stress Index (OSI).
  • Data collected between January 1, 2019, and July 25, 2019, at two tertiary hospitals.

Main Results:

  • RRMS patients with migraine exhibited significantly lower vitamin D and VITDR levels compared to those without migraine.
  • Antioxidant markers (SOD, CAT, GSH-Px, TAS) were reduced, while oxidative stress markers (hs-CRP, TOS) were elevated in RRMS patients with migraine.
  • No significant difference in VITDBP levels was observed between RRMS patients with and without migraine.

Conclusions:

  • This study is the first to examine vitamin D and oxidative stress markers in the context of MS and migraine comorbidity.
  • Findings suggest a potential role for vitamin D deficiency and increased oxidative stress in the etiopathogenesis of MS-migraine coexistence.
  • Further research is warranted to elucidate the complex relationship and its clinical implications for developing novel treatments.