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Published on: June 2, 2014
Why do multiple sclerosis and migraine coexist?
Mehmet Hamamcı1, Ayse Yesim Göcmen2, Bahar Say3
1Department of Neurology, Bozok University Medical School, Yozgat, Turkey.
Background:
Migraine coexistence, which is high in multiple sclerosis (MS), is reported. To better understand the etiology of the coexistence of MS and migraine and the outcomes of this relationship, the vitamin D, vitamin D-binding protein (VITDBP), vitamin D receptor (VITDR), high-sensitivity C-reactive protein (hs-CRP), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), total antioxidant status (TAS), total oxidant status (TOS), and Oxidative Stress Index (OSI) values were examined in patients with the coexistence of relapsing-remitting multiple sclerosis (RRMS) and migraine.
Methods:
This study was conducted between January 1, 2019, and July 25, 2019, at the neurology and biochemistry clinics of two different tertiary hospitals simultaneously. Overall, 50 RRMS patients with migraine, 50 RRMS patients without migraine, and 50 healthy volunteers were included in the study. The participants' vitamin D, VITDBP, VITDR, hs-CRP, SOD, CAT, GSH-Px, TAS, TOS, and OSI values were measured.
Results:
The vitamin D and VITDR values of the RRMS patients with migraine were lower than those of the RRMS patients without migraine (respectively, p = 0.014, p < 0.001). There was no significant difference between the RRMS patients with and without migraine in terms of their VITDBP values (p = 0.570). The SOD, CAT, GSH-Px, and TAS values of the RRMS patients with migraine were lower than those without migraine (all p < 0.001). The hs-CRP and TOS values of the RRMS patients with migraine were higher than those without migraine (all p < 0.001).
Conclusion:
To the best of our knowledge, this is the first study on this topic to date. Based on the results, our study may shed light on the etiopathogenesis of the coexistence of MS and migraine and new treatments. However, more studies are needed to better understand the etiology of this relationship and its negative effects.
Insights
Migraine and multiple sclerosis (MS) coexistence is linked to lower vitamin D and antioxidant levels, alongside higher oxidative stress markers in relapsing-remitting MS (RRMS) patients. Further research is needed to understand this relationship and its impact on treatment.
Area of Science:
- Neurology
- Biochemistry
- Immunology
Background:
- Migraine is frequently observed in patients with multiple sclerosis (MS).
- Understanding the underlying mechanisms of MS and migraine comorbidity is crucial for patient outcomes.
- This study investigates biochemical markers associated with the coexistence of MS and migraine.
Purpose of the Study:
- To investigate the relationship between vitamin D metabolism, oxidative stress markers, and the coexistence of relapsing-remitting multiple sclerosis (RRMS) and migraine.
- To compare these markers in RRMS patients with and without migraine, and healthy controls.
- To explore potential etiological factors and therapeutic targets for MS-migraine comorbidity.
Main Methods:
- Cross-sectional study involving 50 RRMS patients with migraine, 50 RRMS patients without migraine, and 50 healthy volunteers.
- Biochemical analysis of vitamin D, vitamin D-binding protein (VITDBP), vitamin D receptor (VITDR), high-sensitivity C-reactive protein (hs-CRP), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), total antioxidant status (TAS), total oxidant status (TOS), and Oxidative Stress Index (OSI).
- Data collected between January 1, 2019, and July 25, 2019, at two tertiary hospitals.
Main Results:
- RRMS patients with migraine exhibited significantly lower vitamin D and VITDR levels compared to those without migraine.
- Antioxidant markers (SOD, CAT, GSH-Px, TAS) were reduced, while oxidative stress markers (hs-CRP, TOS) were elevated in RRMS patients with migraine.
- No significant difference in VITDBP levels was observed between RRMS patients with and without migraine.
Conclusions:
- This study is the first to examine vitamin D and oxidative stress markers in the context of MS and migraine comorbidity.
- Findings suggest a potential role for vitamin D deficiency and increased oxidative stress in the etiopathogenesis of MS-migraine coexistence.
- Further research is warranted to elucidate the complex relationship and its clinical implications for developing novel treatments.
