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A liposomal contrast agent. Preliminary communication.

C Musu¹, E Felder, B Lamy

¹Bracco Industria Chimica S.p.A., Milano, Italy.

Investigative Radiology

|September 1, 1988

Summary

Iopamidol liposomes show promise as hepatosplenographic contrast agents. Extrusion improved liposome characteristics and altered in vivo distribution, enhancing spleen uptake and reducing lung accumulation for better computed tomography imaging.

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Area of Science:

Biomedical Imaging
Nanotechnology
Radiology

Background:

Liposomes are investigated as carriers for contrast agents.
Hepatosplenographic contrast agents are crucial for liver and spleen imaging.
Iopamidol is a common iodinated contrast agent.

Purpose of the Study:

To evaluate iopamidol-loaded liposomes as hepatosplenographic contrast agents.
To investigate the effect of extrusion on liposome properties and biodistribution.
To assess the computed tomography imaging performance of these liposomes.

Main Methods:

Preparation of large unilamellar vesicles (LUVs) with iopamidol.
Characterization of liposome size, size distribution, and iodine/lipid (I/L) ratio.
In vivo biodistribution studies in rats comparing extruded and non-extruded liposomes.

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Computed tomography (CT) imaging of rat livers.

Main Results:

Liposomes exhibited favorable entrapment of iopamidol.
Extrusion reduced liposome size and increased the I/L ratio.
Extruded liposomes showed higher spleen uptake and reduced lung accumulation compared to non-extruded.
CT scans demonstrated significant liver contrast enhancement (≥60 HU) for up to 240 minutes.

Conclusions:

Iopamidol-carrying liposomes are effective hepatosplenographic contrast agents.
Liposome extrusion optimizes characteristics for improved in vivo performance.
These liposomes offer potential for enhanced diagnostic imaging of the liver and spleen.