Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Contrast media-induced ventricular fibrillation.

K Hayakawa1, K Yamashita

  • 1Department of Radiology, Kyoto City Hospital, Japan.

Investigative Radiology
|September 1, 1988
PubMed
Summary

Contrast media (CM) with high osmolality or lacking sodium ions significantly increased ventricular fibrillation risk in canine studies. Physiologic sodium levels in low-osmolality CM reduced this risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immediate-type hypersensitivity response followed by a late reaction is induced by repeated epicutaneous application of contact sensitizing agents in mice.

The Journal of investigative dermatology·1995
Same author

Distributions of nitropyrenes and mutagenicity in airborne particulates collected with an Andersen sampler.

Mutation research·1995
Same author

B-lineage differentiation stages resolved by multiparameter flow cytometry.

Annals of the New York Academy of Sciences·1995
Same author

Soluble c-kit molecule in serum from healthy individuals and patients with haemopoietic disorders.

British journal of haematology·1995
Same author

Hyperfractionated and hypofractionated radiation therapy for human malignant glioma xenograft in nude mice.

Japanese journal of cancer research : Gann·1995
Same author

[A case of huge renal hamartoma].

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology·1995

Area of Science:

  • Cardiovascular Research
  • Medical Imaging
  • Pharmacology

Background:

  • Contrast media (CM) are crucial for medical imaging procedures like coronary arteriography.
  • Certain CM formulations have been associated with adverse cardiac events, including ventricular fibrillation.
  • Understanding the specific properties of CM that influence arrhythmogenicity is vital for patient safety.

Purpose of the Study:

  • To evaluate the incidence of ventricular fibrillation induced by different types of contrast media during canine right coronary arteriography.
  • To determine the relationship between contrast media osmolality, sodium ion concentration, and the risk of ventricular fibrillation.

Main Methods:

  • Canine right coronary arteriography was performed.
  • Contrast media were infused continuously into the right coronary artery for 25 seconds or until ventricular fibrillation occurred.
  • The incidence of ventricular fibrillation was recorded for various contrast media formulations.

Main Results:

  • High-osmolality contrast media showed a significantly higher incidence of ventricular fibrillation.
  • Low-osmolality contrast media lacking sodium ions also resulted in a significantly higher incidence of ventricular fibrillation.
  • Low-osmolality contrast media containing physiologic amounts of sodium ions exhibited a significantly lower incidence of ventricular fibrillation.

Conclusions:

  • Hyperosmolality of contrast media is a contributing factor to ventricular fibrillation.
  • The absence of sodium ions in contrast media, even those with low osmolality, increases the risk of ventricular fibrillation.
  • Contrast media formulations with physiologic sodium concentrations are safer regarding arrhythmogenic potential.

Related Experiment Videos