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Hypofractionated Radiation Therapy for Progressive Heterotopic Ossification: The Relationship between Dose and
Dong Soo Lee1, Youngwoo Kim2, Hang Joo Cho3
1Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
International Journal of Radiation Oncology, Biology, Physics
|January 28, 2020
Summary
Hypofractionated radiation therapy (RT) effectively managed progressive heterotopic ossification (HO), with higher doses potentially improving outcomes. Most patients experienced HO reduction and maintained status post-treatment without significant toxicity.
Area of Science:
- Orthopedics
- Radiation Oncology
Background:
- Heterotopic ossification (HO) is abnormal bone formation that can impair joint function.
- Progressive HO requires effective management strategies to prevent further complications.
Purpose of the Study:
- To evaluate treatment outcomes of hypofractionated short-course radiation therapy (RT) for progressive heterotopic ossification (HO).
Main Methods:
- Nine patients with progressive HO received RT between January 2016 and December 2018.
- Various RT dose-fractionation regimens were used, including 7 Gy x 2, 9 Gy x 1, 6 Gy x 2, 6 Gy x 3, 8 Gy x 2, and 7 Gy x 3 fractions.
- Patients were assessed for HO progression, Brooker's grade, and RT-related toxicity.
Main Results:
- Eight of nine patients showed decreased HO, with five experiencing a dramatic reduction (≥50%).
- HO status was maintained at follow-up, and Brooker's grade improved in three patients.
- No significant RT-related toxicity was observed.
Conclusions:
- Hypofractionated RT is an effective treatment for managing progressive HO.
- Higher RT doses may be associated with superior efficacy in treating progressive HO.
