Knowledge and attitudes on pharmacogenetics among pediatricians

Area of Science:

• Clinical Pharmacology
• Genetics
• Pediatrics

Background:

• Clinical pharmacogenetic testing is growing, requiring pediatricians to interpret results.
• Previous studies show a knowledge gap in pharmacogenetics across specialties, but not specifically in pediatrics.

Purpose of the Study:

• To assess U.S. and Japanese pediatricians' knowledge, attitudes, and educational needs regarding pharmacogenetics.

Main Methods:

• Anonymous survey of 282 pediatricians (210 U.S., 72 Japan) on pharmacogenetics knowledge, perception, and education.
• Survey included questions on clinical experience, prior genetics education, and specific pharmacogenetic knowledge (e.g., codeine/CYP2D6).

Main Results:

• Despite >10 years of experience for over 50%, <10% felt familiar with pharmacogenetics.
• Fewer than 20% of U.S. pediatricians answered a CYP2D6 question correctly, and <10% knew of CPIC guidelines.
• Over 80% believed pharmacogenetic testing improves efficacy/safety and want to apply it, with 83.1% interested in education.

Conclusions:

• Pediatrician knowledge of clinical pharmacogenetics is currently low in the U.S. and Japan.
• There is strong interest among pediatricians for pharmacogenetics education, particularly in result interpretation and treatment recommendations.
• High interest suggests a readiness to adopt pharmacogenetic testing, facilitating future clinical implementation.