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Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation
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High density lipoprotein mimicking nanoparticles for atherosclerosis

Jun Chen1, Xixi Zhang1, Reid Millican1

  • 1Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.

Nano Convergence
|January 28, 2020
PubMed

Insights

High-density lipoproteins (HDL) mimic nanoparticles offer promising therapeutic strategies for atherosclerosis, a leading cause of global mortality. This review highlights recent advancements in HDL-mimicking nanoparticles for imaging, targeting, and treating atherosclerosis.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Nanotechnology

Background:

  • Atherosclerosis is a primary cause of global mortality, contributing to myocardial infarction, ischemic stroke, and peripheral arterial disease.
  • High-density lipoproteins (HDL), or "good cholesterol", exhibit anti-atherosclerotic properties by facilitating cholesterol removal from plaque foam cells.

Purpose of the Study:

  • To review recent progress in the development of HDL-mimicking nanoparticles (NPs).
  • To summarize the applications of these HDL-mimicking NPs in imaging, targeting, and treating atherosclerosis.

Main Methods:

  • Literature review of recent advancements in HDL-mimicking nanoparticle design.
  • Analysis of studies focusing on the application of these nanoparticles in atherosclerosis.

Main Results:

  • Significant progress has been made in designing functional HDL-mimicking NPs.
  • These NPs show potential for various applications in atherosclerosis management.

Conclusions:

  • HDL-mimicking NPs represent a promising therapeutic avenue for atherosclerosis.
  • Further development and application of these NPs are crucial for combating cardiovascular disease.

Keywords:
AtherosclerosisHigh-density lipoproteinImaging contrast agentsNanoparticlesTheranostic agentsTherapeutic delivery

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