Related Experiment Video

Updated: Dec 30, 2025

Performing Colonoscopic-Guided Pinch Biopsies in Mice and Evaluating Subsequent Tissue Changes
08:52

Performing Colonoscopic-Guided Pinch Biopsies in Mice and Evaluating Subsequent Tissue Changes

Published on: February 5, 2021

4.8K

Histopathologic ─ Endoscopic Concordance of Pediatric Duodenal Biopsy; How to Be Improved?

Khadiga Mohamed Ali1, Khaled R Zalata2, Tarik Barakat3

  • 1Faculty of Medicine, Department of Pathology, Mansoura University, Mansoura, Egypt.

Fetal and Pediatric Pathology
|January 28, 2020
PubMed

Insights

Pediatric duodenal biopsies reveal more pathology than initially seen during endoscopy. Routine biopsies are crucial, even from normal-appearing duodenal tissue, to accurately diagnose conditions in children.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Pathology
  • Endoscopic Diagnostics

Background:

  • Correlation between endoscopic appearance and biopsy results in pediatric duodenal pathology is not well-established.
  • Accurate diagnosis of duodenal conditions in children is essential for appropriate management.

Purpose of the Study:

  • To evaluate the concordance between gross endoscopic impressions and histopathologic findings of duodenal biopsies in pediatric patients.
  • To determine the diagnostic yield of routine duodenal biopsies in children.

Main Methods:

  • Retrospective analysis of 1793 children undergoing upper gastrointestinal endoscopy over 11 years.
  • Comparison of endoscopic observations with histopathologic examination of duodenal biopsies.
  • Calculation of sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for endoscopic findings.

Main Results:

  • Duodenal pathology was identified in 72.3% of the pediatric patients studied.
  • Gross endoscopic findings demonstrated low sensitivity (38.9%) and high specificity (99.2%) for detecting duodenal pathology.
  • Overall concordance between endoscopic and histopathologic analysis was 55.6%.

Conclusions:

  • Histopathologic analysis reveals a significantly higher rate of pediatric duodenal pathologies than gross endoscopic assessment.
  • Routine duodenal biopsies, even from macroscopically normal mucosa, are valuable for accurate diagnosis in children.
  • Emphasizes the importance of histopathological confirmation for pediatric duodenal diseases.
Abstract

Keywords:
Upper gastrointestinal endoscopiesceliac diseasechildrenconcordanceduodenal pathology

More Related Videos

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry11:02

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry

Published on: January 20, 2017

9.6K

Related Concept Videos

Endoscopic Procedures V: ERCP01:26

Endoscopic Procedures V: ERCP

Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
2.3K
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
473
Endoscopic Procedures I: Esophagogastroduodenoscopy01:29

Endoscopic Procedures I: Esophagogastroduodenoscopy

An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
732