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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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Related Experiment Video

Updated: Dec 30, 2025

In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages

In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages

Published on: November 1, 2019

Platelets and extracellular traps in infections.

Ricardo M Gómez^1,2, Aída O López Ortiz^1,3, Mirta Schattner³

¹Laboratorio De Virus Animales, Instituto De Biotecnología Y Biología Molecular, CONICET-UNLP, La Plata, Argentina.

|January 28, 2020

Summary

Platelets significantly influence the formation of extracellular traps (ETs), a key immune defense mechanism. This review explores platelets

Keywords:

Bacteria extracellular traps infections macrophage neutrophils platelets virus

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Area of Science:

Immunology
Cell Biology
Hematology

Background:

Platelets are crucial in hemostasis, thrombosis, and immune responses.
Extracellular traps (ETs) are DNA-protein complexes released by immune cells to trap pathogens.
While neutrophils are known NET producers, other leukocytes also form ETs.

Purpose of the Study:

To review the current understanding of platelet involvement in ET formation.
To highlight the physiopathological roles of platelet-modulated ETs in infection.
To discuss future research directions in this field.

Main Methods:

Literature review of recent studies on platelets and ETs.
Analysis of experimental data on platelet-ET interactions.
Synthesis of findings regarding ETs in infectious contexts.

Main Results:

Platelets actively modulate the formation of various ET types.
Platelet-derived factors can promote or inhibit ET release.
Platelet-ET interactions play a significant role in host defense during infection.

Conclusions:

Platelets are key regulators of ET formation with critical roles in immunity.
Understanding platelet-ET interplay offers therapeutic potential for infectious diseases.
Further research is needed to fully elucidate these complex interactions.