Related Experiment Video
Updated: Dec 30, 2025
09:50
Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
9.7K
Flavones as a Privileged Scaffold in Drug Discovery: Current Developments
Pone K Boniface1, Ferreira I Elizabeth1
1Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Current Organic Synthesis
|January 28, 2020
Summary
Flavones, a class of flavonoids, exhibit significant pharmacological properties. This review highlights their potential in treating diseases, emphasizing the need for further research and development of flavone-based therapies.
Area of Science:
- Pharmacology
- Medicinal Chemistry
Background:
- Flavones are a major subclass of flavonoids.
- They possess diverse pharmacological properties, including antimalarial, antimicrobial, antioxidant, and anti-inflammatory activities.
Purpose of the Study:
- To review recent information on the pharmacological properties of natural and synthetic flavones.
- To consolidate current knowledge on flavone bioactivity.
Main Methods:
- A comprehensive literature search was conducted.
- Databases searched include SciFinder, PubMed, Science Direct, Wiley, ACS, SciELO, and Springer.
- Publications on natural and synthetic flavones and their biological activities were hand-searched.
Main Results:
- Seventy-five natural flavones were identified as active compounds in in vitro studies (IC50 < 20 µg/mL).
- Synthetic flavones demonstrated activity against various diseases.
Conclusions:
- Flavones are promising sources for treating multifactorial diseases.
- Further development of flavone-based therapeutic agents is necessary.
- Advancements in synthesis are expected to uncover novel flavones with enhanced properties.
Related Concept Videos
01:26Drug Discovery: Overview
10.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.8K
01:28Structure-Activity Relationships and Drug Design
1.6K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.6K
01:27Bioavailability Enhancement: Drug Permeability Enhancement
145
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
145
01:26Targets for Drug Action: Overview
9.9K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
9.9K
01:22Biopharmaceutical Factors Influencing Drug Product Design: Overview
160
Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
160
01:16Drug Delivery: Overview
663
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
663