Related Experiment Video
Updated: Dec 30, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
Enantio- and Substrate-Selective Recognition of Chiral Neurotransmitters with C3-Symmetric Switchable Receptors
Jian Yang1, Bastien Chatelet1, Véronique Dufaud2
1Aix Marseille Univ., CNRS, Centrale Marseille, iSm2 , Marseille 13397 , France.
Abstract:
We report on the synthesis of C3-symmetric enantiopure cage molecules 1, which exhibit remarkable to exclusive enantioselective recognition properties toward chiral ammonium neurotransmitters. Strong changes in the substrate selectivity are also observed when different stereoisomers of 1 are used. Furthermore, protonation/deprotonation induces a reversible modification of the conformation of 1, which switches from an imploded to an inflated form, leading to ejection and reuptake of the guest initially encaged inside the cavity.
Related Concept Videos
Prochirality
Chirality in Nature
Ligand-Gated Ion Channel Receptor: Gating Mechanism
¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...

