Related Experiment Video
Updated: Dec 30, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.4K
Safety considerations with combination therapies for psoriasis
1Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
Expert Opinion on Drug Safety
|January 28, 2020
Summary
Combination therapy offers a valuable strategy for managing psoriasis, a chronic skin condition. Combining treatments with different mechanisms can improve disease control and minimize side effects.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Psoriasis is a chronic inflammatory skin disease with variable severity and challenging long-term remission.
- Current treatments include topical agents, phototherapy, oral systemic agents, and biologics, with ongoing development of new therapies.
Purpose of the Study:
- To review combination therapy strategies for psoriasis, including rotational and sequential approaches.
- To describe safe and effective combination therapies for achieving and maintaining adequate disease control.
- To address the challenges in selecting combination regimens that balance efficacy, safety, usability, and compliance.
Main Methods:
- Review of existing literature on psoriasis treatment strategies.
- Analysis of combination therapy approaches, considering different mechanisms of action and safety profiles.
- Discussion of therapeutic agents for recalcitrant disease and patient compliance factors.
Main Results:
- Combination therapy can enhance disease control and minimize treatment toxicity by using agents with different action mechanisms.
- Sequential and rotational therapy are viable combination strategies.
- Careful consideration of safety, efficacy, usability, and compliance is essential when choosing combination regimens.
Conclusions:
- Combination therapy is a crucial and valuable strategy for managing psoriasis, especially with new agents emerging.
- Clinicians must carefully balance the safety and efficacy of combined therapeutic agents.
- Future research should focus on optimizing combination regimens for improved patient outcomes.
Keywords:
Psoriasisbiologicscombination therapyphototherapyrotational therapysafetysequential therapysystemic therapyMore Related Videos
Related Concept Videos
01:27Combined Effects of Drugs: Synergism
6.6K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
6.6K
01:28Drug Therapy
205
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
205
02:50Combination Therapies and Personalized Medicine
5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
01:29Therapeutic Drug Monitoring: Affecting Factors
140
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
140
01:25Pharmacokinetics: Drug–Drug Interactions
278
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
278
01:24Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
1.2K
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
1.2K