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Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Application
Mukesh C Joshi1, Timothy J Egan2
1Department of Chemistry, Motilal Nehru College, Benito Juarez Marg, South Campus, University of Delhi, New Delhi- 110021, India.
Abstract:
The side-chains of quinoline antimalarial agents are the major concern of focus to build novel and efficaciaous bioactive and clinical antimalarials. Bioative antimalarial analogs may play a critical role in pH trapping in the food vacuole of RBC's with the help of fragmented amino acid, thus lead to β-hematin inhibition. Here, the authors tried to summarize a useful, comprehensive compilation of side-chain modified ACQs along with their synthesis, biophysical and therapeutic applications etc. of potent antiplasmodial agents and therefore, opening the door towards the potential clinical status.
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