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Baseline Variables Associated with Functional Decline in 2CARE, A Randomized Clinical Trial in Huntington's Disease.

Andrew McGarry1, Michael P McDermott2, Karl Kieburtz2

  • 1Cooper University Healthcare at Rowan University, Camden, NJ, USA.

Journal of Huntington'S Disease
|January 28, 2020
PubMed
Summary

Huntington's disease (HD) patients with worse motor/cognitive scores, lower weight, and longer CAG repeats experience faster functional decline. Female sex was also associated with more rapid progression in this study.

Keywords:
Huntington’s diseaseclinical trialfunctional declinetotal functional capacity

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Area of Science:

  • Neurology
  • Genetics
  • Clinical Trials

Background:

  • Huntington's disease (HD) is characterized by progressive functional decline.
  • Factors influencing the rate of this decline require further investigation.

Purpose of the Study:

  • To identify risk factors associated with accelerated functional decline in Huntington's disease.
  • To leverage data from a clinical trial to understand disease progression.

Main Methods:

  • Analysis of data from the 2CARE randomized clinical trial.
  • Inclusion of up to 5 years of patient follow-up data.
  • Assessment of various clinical and genetic variables as potential risk factors.

Main Results:

  • Worse motor performance and cognitive test scores correlated with faster functional decline.
  • Lower body weight, lower body mass index, and higher CAG repeat length were associated with accelerated progression.
  • Female sex and younger age at onset were also linked to faster decline, particularly with longer CAG repeat lengths.

Conclusions:

  • Identified risk factors, including motor/cognitive status, weight, and CAG repeat length, can inform management strategies for Huntington's disease.
  • The faster progression observed in females warrants further investigation, considering potential confounding factors like weight.