Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

192
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
192
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

214
Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
214
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

294
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
294
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

254
Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
254
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

162
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
162
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

283
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
283

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Adverse Events on Costs and Length of Stay Following Transcatheter Tricuspid Valve Replacement.

Structural heart : the journal of the Heart Team·2026
Same author

Outcomes of Self-Expanding Versus Balloon-Expandable Transcatheter Aortic Valves in Patients With Reduced Left Ventricular Ejection Fraction: A Meta-Analysis of Observational Studies.

Structural heart : the journal of the Heart Team·2026
Same author

Lifetime management of aortic stenosis: A primer for the generalist.

The American journal of medicine·2026
Same author

Impact of TAVR Failure Mechanism on Outcomes After Reintervention: From the EXPLANTORREDO-TAVR Registry.

Circulation. Cardiovascular interventions·2026
Same author

Real-World Outcomes of Transcatheter Tricuspid Valve Replacement: Analysis From the STS/ACC TVT Registry.

JAMA·2026
Same author

Cost-Effectiveness of Valve-in-Valve Transcatheter Mitral Valve Replacement Versus Redo Surgical Mitral Valve Replacement for Degenerated Bioprosthetic Mitral Valve.

Structural heart : the journal of the Heart Team·2026

Related Experiment Video

Updated: Dec 30, 2025

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

4.3K

Transcatheter Mitral Valve Replacement: Rationale and Current Status.

Paul N Fiorilli1, Howard C Herrmann1

  • 1Cardiovascular Medicine Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; email: paul.fiorilli@uphs.upenn.edu, howard.herrmann@uphs.upenn.edu.

Annual Review of Medicine
|January 28, 2020
PubMed
Summary
This summary is machine-generated.

Mitral regurgitation (MR) is common valve disease. Transcatheter mitral valve replacement (TMVR) offers an alternative to surgery, with devices under development and requiring careful patient selection.

Keywords:
TMVRmitral regurgitationmitral valve replacementmitral valve surgerytranscatheter valve therapies

More Related Videos

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

2.1K
Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

3.2K

Related Experiment Videos

Last Updated: Dec 30, 2025

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

4.3K
Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

2.1K
Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

3.2K

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Devices

Background:

  • Mitral regurgitation (MR) is the most common moderate-to-severe heart valve disease globally.
  • MR, whether primary or secondary, significantly increases patient morbidity and mortality.
  • Transcatheter therapies are emerging to mitigate surgical risks.

Purpose of the Study:

  • To review the development and current status of transcatheter mitral valve replacement (TMVR).
  • To highlight the limitations of current transcatheter repair techniques.
  • To emphasize the need for a heart team approach in TMVR decision-making.

Main Methods:

  • Review of current transcatheter mitral valve replacement devices and trials.
  • Analysis of limitations in existing transcatheter mitral valve repair.
  • Discussion of patient-, disease-, and device-specific factors for TMVR.

Main Results:

  • Transcatheter mitral valve replacement (TMVR) is being actively developed with various device approaches (transapical, transseptal).
  • Early feasibility and pivotal trials for TMVR devices are ongoing.
  • Current transcatheter repair methods face challenges with therapeutic targets and efficacy.

Conclusions:

  • Transcatheter mitral valve replacement (TMVR) represents a promising alternative for patients with mitral regurgitation.
  • The selection of patients for TMVR necessitates a comprehensive heart team evaluation.
  • Ongoing clinical trials are crucial for establishing the role of TMVR in managing mitral regurgitation.