Related Experiment Video

Updated: Dec 30, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.8K

Cardiac Amyloidosis: Overlooked, Underappreciated, and Treatable

Jonah Rubin1, Mathew S Maurer1

  • 1Clinical Cardiovascular Research Laboratory for the Elderly, Columbia University Irving Medical Center, Allen Hospital of NewYork-Presbyterian Hospital, New York, NY 10032, USA; email: yonahrubin@gmail.com, msm10@cumc.columbia.edu.

Annual Review of Medicine
|January 28, 2020
PubMed

Insights

Cardiac amyloidosis (CA) is a serious heart condition often missed. New diagnostic tools and treatments are improving outcomes for transthyretin cardiac amyloidosis (ATTR-CA) and light chain cardiac amyloidosis (AL-CA).

Area of Science:

  • Cardiology
  • Internal Medicine
  • Genetics

Background:

  • Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy leading to heart failure.
  • Two main subtypes exist: transthyretin (ATTR-CA) and light chain (AL-CA).
  • CA is underdiagnosed, particularly as a cause of heart failure with preserved ejection fraction.

Purpose of the Study:

  • To review the epidemiology, pathophysiology, diagnosis, prognosis, and management of CA.
  • To highlight recent advancements in CA diagnosis and treatment.
  • To discuss future directions in the field of CA.

Main Methods:

  • Literature review focusing on epidemiology, pathophysiology, diagnosis, prognosis, and management of CA.
  • Emphasis on recent diagnostic and therapeutic developments.
  • Synthesis of current knowledge and future perspectives.

Main Results:

  • Cardiac amyloidosis (CA) encompasses ATTR-CA (wild-type and variant) and AL-CA.
  • Nuclear scintigraphy enables non-biopsy diagnosis of ATTR-CA.
  • Emerging treatments include transthyretin stabilizers and silencers.

Conclusions:

  • Early and accurate diagnosis of CA is critical due to improved management options.
  • Recent advances in diagnostics and therapeutics are transforming CA care.
  • Further research and clinical attention are needed to address underdiagnosis and optimize patient outcomes.

Keywords:
agingcardiac amyloidosiscardiomyopathyheart failurelight chaintransthyretin

More Related Videos

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA13:10

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA

Published on: April 24, 2017

19.1K
Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction08:31

Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction

Published on: July 26, 2018

10.8K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
307
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
427
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
253
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
385
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
380
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
248