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Design, synthesis, and biological evaluation of novel 4H-chromen-4-one derivatives as antituberculosis agents against

Wenting Zhao1, Bin Wang2, Yuke Liu3

  • 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China.

European Journal of Medicinal Chemistry
|January 28, 2020
PubMed

Keywords:
4H-chromen-4-oneAntitubercular agentsMultidrug-resistant tuberculosisPolyketide synthase 13Scaffold morphing

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