Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diurnal Variation of Islet Autoantibody Titers in Established Type 1 Diabetes Suggests Restricted-Time Sampling Improves Aab Measurement and Detection.

Research square·2026
Same author

GADA testing: preparation for adult general population screening.

Diabetologia·2026
Same author

Improved prediction of symptomatic type 1 diabetes using a luciferase-based assay to measure (pro)insulin autoantibodies.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same author

The Downregulation of Type 1 Diabetes Susceptibility Gene PGM1 Induces Metabolic Imbalance and Stress in Pancreatic β-Cells.

Diabetes·2026
Same author

Relative maternal protection against type 1 diabetes: a combined analysis of five observational studies.

The Journal of clinical endocrinology and metabolism·2026
Same author

Profiling peripheral blood oxidative stress in multiple sclerosis.

Multiple sclerosis and related disorders·2026
Same journal

Neuromyelitis optica spectrum disorder: a 5-year experience in a tertiary hospital in Northern Vietnam.

Multiple sclerosis and related disorders·2026
Same journal

Cell-type-specific Mendelian randomization analysis of brain single-nucleus eQTLs and neuromyelitis optica spectrum disorder risk.

Multiple sclerosis and related disorders·2026
Same journal

Detection of Aquaporin-4 antibody in cerebrospinal fluid in neuromyelitis optica spectrum disorder.

Multiple sclerosis and related disorders·2026
Same journal

Adjunctive gypenosides for acute optic neuritis: A prematurely terminated randomized, double-blind, placebo-controlled pilot trial in a cohort with frequent AQP4-IgG positivity.

Multiple sclerosis and related disorders·2026
Same journal

Genetic and molecular architecture of multiple sclerosis in gulf cooperation council populations: A scoping review and regional precision-neurology perspective.

Multiple sclerosis and related disorders·2026
Same journal

Rising burden and future projections of multiple sclerosis in East Asia: Findings from the global burden of disease study 2021.

Multiple sclerosis and related disorders·2026
See all related articles

Related Experiment Video

Updated: Dec 30, 2025

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice
08:49

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Published on: October 6, 2023

2.3K

Maternal micro-chimeric cells in the multiple sclerosis brain.

Heidi Snethen1, Jody Ye2, Kathleen M Gillespie2

  • 1MS and stem cell group, Clinical Neuroscience, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

Multiple Sclerosis and Related Disorders
|January 28, 2020
PubMed
Summary
This summary is machine-generated.

Maternal microchimeric cells (MMC) are common in adult brains, even in healthy individuals. These cells, originating from the mother, were found in both healthy brains and those with multiple sclerosis (MS).

Keywords:
Maternal microchimerismMultiple sclerosis

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.9K
Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination
04:53

Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination

Published on: April 5, 2022

4.0K

Related Experiment Videos

Last Updated: Dec 30, 2025

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice
08:49

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Published on: October 6, 2023

2.3K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.9K
Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination
04:53

Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination

Published on: April 5, 2022

4.0K

Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Maternal microchimeric cells (MMC) transfer from mother to child during pregnancy.
  • MMC are found in healthy adults but are more concentrated in autoimmune diseases.
  • The presence of MMC in the brain, particularly in autoimmune neurological conditions, is unexplored.

Purpose of the Study:

  • To identify and quantify maternal microchimeric cells (MMC) in adult human brain tissue.
  • To investigate the prevalence of MMC in individuals with multiple sclerosis (MS) compared to controls.
  • To explore the phenotype of MMC within brain tissue.

Main Methods:

  • Utilized fluorescent in situ hybridization (FISH) with X and Y chromosome probes.
  • Examined post-mortem brain tissue from male MS cases and male control cases.
  • Performed cell-specific labeling to identify cell types.

Main Results:

  • Female cells (presumed MMC) were detected in 5/6 MS cases and 6/6 control cases.
  • MMC were identified in both control brain tissue and active MS lesions.
  • Female cells of neuronal and immune phenotypes were found in the brain tissue.

Conclusions:

  • Maternal microchimeric cells (MMC) are a common finding in the adult human brain.
  • These cells appear to embed within brain tissue and can express tissue-specific markers.
  • The presence and potential role of MMC in neurological conditions like MS warrant further investigation.