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9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds
Francesco Calogero1, Stella Borrelli1, Gaetano Speciale1
1Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano (Italy).
Chempluschem
|January 29, 2020
Abstract:
The introduction of a hydrophobic group at position 7 of 9-fluorenone-2-carboxylic acid generates new tubulin binders, the design of which is suggested by modeling studies. The synthesis is based on the use of 2,7-dibromo-fluorenone as starting material. The antiproliferative activity on two different cell lines, fluorescent microscopy, flow cytometry, and sedimentation assay tests confirmed the supposed mechanism.

