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Modular Synthesis of Optically Active Tröger's Base Analogues

Takuya Kamiyama1, Merve Sinem Özer2, Elisabeth Otth1

  • 1Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zurich, HCI H230, Wolfgang-Pauli-Strasse 10, 8093 Zürich (Switzerland), Fax: (+41) 44-6321310.

Chempluschem
|January 29, 2020
PubMed
Summary

Enantioselective catalysis and enzymatic resolution enable scalable synthesis of enantiopure Tröger's base derivatives. This provides valuable N-stereogenic building blocks for diverse chemical modifications.

Keywords:
Tröger’s basebiocatalysischiralitycross-couplingkinetic resolution

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