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Updated: Dec 30, 2025
Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
Published on: July 14, 2015
Synthesis of Polyboronic Acid Functionalized Hierarchically Ordered Macro-/Mesoporous Silica for Selective Enrichment
Yinghua Yan1, Chunhui Deng1, Zhifang Zheng1
1Department of Chemistry and Institutes of Biomedical Science, Fudan University, Shanghai 200433 (P. R. China), Fax: (+86) 21-65641740.
Abstract:
A novel hierarchically ordered macro/mesoporous silica was functionalized with polyboronic acid (HOMMS@PolyVPBA). This composite possesses the attractive features of high surface area and large accessible porosity, and was applied to enrich glycopeptides. Here the HOMMS material was introduced into glycoproteome for the first time. The HOMMS@PolyVPBA gave remarkable selectivity for glycopeptides even at a low molar ratio of glycopeptides/nonglycopeptides (1:50) with a very rapid enrichment speed (only 10 min) and low detection (1 ng μL-1 ). Therefore the synthetic HOMMS@PolyVPBA might be a promising selective enrichment material for glycoproteome analysis.
