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Published on: October 28, 2015
Encapsulated Ruthenium(II) Complexes in Biocompatible Poly(d,l-lactide-co-glycolide) Nanoparticles for Application in
Gaëlle Bœuf1,2, Gaëlle V Roullin1, Juliette Moreau1
1ICMR-UMR CNRS no. 7312, Université de Reims Champagne-Ardenne, BP 1039-51687 Reims cedex 2 (France), Fax: (+33) (0)3-26-91-32-43.
Abstract:
The elaboration, characterisation and efficiency of potential two-photon-excited photodynamic therapy (PDT) treatment of new poly(d,l-lactide-co-glycolide) nanoparticles loaded with ruthenium(II) complexs are presented. The materials are based on the encapsulation of RuII complexes through an all-biocompatible process. The size of the nanoparticles is around 100 nm. The internal concentration is several orders of magnitude higher than the overall concentration, which leads to a more efficient and targeted effect. The therapeutic potential for PDT of these nanoparticles has been studied in vitro on C6 glioma cells.
