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Related Concept Videos

Peptide Bonds02:43

Peptide Bonds

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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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Peptidoglycan Synthesis01:28

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Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan...
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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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Monocyclic Peptides: Types, Synthesis and Applications.

Yalda Khazaei-Poul1, Shohreh Farhadi1, Sepideh Ghani1

  • 1Department of Medical Biotechnology, School of Advanced Technology in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Current Pharmaceutical Biotechnology
|January 29, 2020
PubMed
Summary

Cyclic peptides offer enhanced stability and potency compared to linear peptides, making them valuable tools in drug discovery and development. Their diverse applications span therapeutics, diagnostics, and agriculture.

Keywords:
Cyclic peptidesmultifunctional toolsnatural peptidessynthetic peptides

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Area of Science:

  • Biochemistry
  • Medicinal Chemistry
  • Molecular Biology

Background:

  • Peptides are versatile biomolecules with broad applications in biological research and development.
  • Peptides are classified into linear and cyclic structures, with cyclic peptides exhibiting superior properties.
  • Monocyclic peptides possess a single macrocyclic ring, offering advantages like enhanced receptor binding, uptake, potency, and stability.

Purpose of the Study:

  • To provide a comprehensive overview of cyclic peptides.
  • To explore the classification, synthesis, and diverse applications of cyclic peptides.
  • To highlight the potential of cyclic peptides in various scientific and industrial fields.

Main Methods:

  • Literature review of existing research on cyclic peptides.
  • Analysis of different categories and synthesis methodologies for cyclic peptides.
  • Compilation and discussion of current and emerging applications of cyclic peptides.

Main Results:

  • Cyclic peptides demonstrate significant advantages over linear counterparts, including improved stability and target interaction.
  • Identified applications include use as pro-apoptotic and antimicrobial agents.
  • Cyclic peptides are effective as targeting ligands for drug delivery and diagnostic agents.

Conclusions:

  • Cyclic peptides represent a promising class of molecules with significant therapeutic and diagnostic potential.
  • Their unique structural features enable enhanced efficacy and targeted delivery.
  • Further research into cyclic peptide synthesis and applications will drive innovation in medicine and agriculture.