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Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
Published on: July 6, 2016
A novel fluorescent probe for selective imaging of cellular cysteine with large Stokes shift and high quantum yield
Yabing Gan1, Guoxing Yin1, Ting Yu1
1Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, China.
Abstract:
A new strategy endowing probe with large Stokes shift, high quantum yield and red emission was developed by incorporating tetrahydroquinoxaline unit and five-membered pyrrolidine ring on fluorophore. As demonstrated, a novel probe was rationally designed and synthesized for sensitive monitor of cellular cysteine (Cys) and endogenous aminoacylase with large Stokes shift and high quantum yield.
