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Updated: Dec 30, 2025

In Vitro Evaluation of Oncogenic Transformation in Human Mammary Epithelial Cells
Published on: September 24, 2020
Burden of cancer mortality attributable to carcinogenic infections in Spain
Pietro Ferrara1, Fernando Agüero2, Cristina Masuet-Aumatell2
1Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", 5, Via Luciano Armanni, Naples 80138, Italy.
Introduction:
The impact of carcinogenic infections on cancer-related mortality is unknown.
Methods:
The mortality due to cancers attributable to carcinogenic infections was estimated. The attributable fraction for the infectious agents classified as group 1 carcinogenic in human beings was applied to yearly data on causes of cancer mortality over the period 2013-2017 in Spain according to the International Classification of Diseases (ICD-10).
Results:
It was estimated that 9115 deaths (over 110,287 cancer-related deaths, 8.3%) were attributable to infections caused by carcinogenic agents. The estimated number of deaths in men was 5434 (59.6%). The estimated mortality attributable to Helicobacter pylori infection accounted for 48.3% and four agents (H. pylori, HCV, HPV, and HBV) accounted for 96.8% of all cancer deaths attributable to carcinogenic infections. The burden of cancer-related mortality attributable to carcinogenic infections in Spain during the period 2013-2017 was approximately 8%.
Conclusions:
In Spain, one-twelfth of cancer deaths are attributable to carcinogenic infections. Public health measures aiming to reduce the impact of carcinogenic infections are essential.
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