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Male hypogonadism: a review
Marco Marcelli1,2, Sanjay Navin Mediwala3,2
1Department of Medicine, Division of Endocrinology, Baylor College of Medicine, Houson, Texas, USA marcelli@bcm.edu.
Summary
This review covers key advancements in male hypogonadism diagnosis and treatment from 2010 to the present. It highlights significant updates in testosterone replacement therapy and clinical management strategies.
Area of Science:
- Endocrinology
- Andrology
- Men's Health
Background:
- Male hypogonadism, characterized by testosterone deficiency, impacts numerous aspects of men's health.
- The Endocrine Society Guidelines of 2010 provided a foundational framework for managing this condition.
- Significant research and clinical practice evolution have occurred since the 2010 guidelines.
Purpose of the Study:
- To systematically review major developments in male hypogonadism.
- To analyze changes in diagnosis, treatment, and management between 2010 and 2018, and post-2018.
- To provide an updated perspective on the current landscape of male hypogonadism care.
Main Methods:
- Systematic literature review methodology.
- Inclusion of studies published between 2010 and present.
- Focus on key developments in male hypogonadism management.
Main Results:
- Identification of evolving diagnostic criteria and therapeutic approaches.
- Analysis of trends in testosterone replacement therapy (TRT) efficacy and safety.
- Documentation of shifts in clinical practice and guideline updates.
Conclusions:
- Male hypogonadism management has seen substantial evolution since 2010.
- Current evidence supports personalized TRT strategies and ongoing monitoring.
- Further research is needed to address remaining clinical questions and optimize patient outcomes.
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