Related Experiment Video
Updated: Dec 29, 2025

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
Treatment of Hypernatremia in Breastfeeding Neonates: A Systematic Review
Adrianne Rahde Bischoff1, Alícia Dorneles Dornelles2, Clarissa Gutierrez Carvalho3,4
1Departmental Clinical Fellowship, Division of Neonatology, Department of Pediatrics, University of Toronto and the Hospital for Sick Children, Toronto, ON, Canada.
Background/Aims:
Hypernatremic dehydration in term neonates is associated with inadequate fluid intake, usually related to insufficient lactation. The use of hypotonic fluids is appropriate to dilute serum sodium (SNa), but cerebral edema may develop when it happens abruptly. Our objective was to clarify how to correct hypernatremic dehydration properly.
Methods:
The following databases were searched, limited to studies published until January 31st, 2016: Clinical Trials, MEDLINE/PubMed, EMBASE, LILACS, and the Cochrane Library. We included open-label trials, nonrandomized controlled trials, or prospective and retrospective case series evaluating relevant outcomes. Information regarding the way of administering the treatment, type of fluid used, rates of complications and outcomes, as well as the rate of SNa reduction were collected.
Results:
Searches yielded 771 articles: 64 had the full text reviewed and 9 were included. No randomized clinical trials or systematic reviews focusing on treatment of hypernatremic dehydration and its outcomes were found. We found a scarcity of high quality studies and great methodology heterogeneity.
Conclusions:
More severe hypernatremia is at greater risk of causing severe adverse effects of treatment. There is no consensus about the optimal rate of SNa drop in this population, but a slower correction appears to be safer. Questions as when parenteral fluids are indicated remain unanswered.
More Related Videos
Related Concept Videos
Nephrotic Syndrome III : Nursing Management
Disorder of Water Balance
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
Acute Kidney Injury VI: Nursing Management
Drug Dosing: Infants and Children
Regulation of Water Intake
Mitral Regurgitation IV: Nursing Management

