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Updated: Dec 29, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
The Long and the Short of Missing Medicines
Denis Horgan1, Robin Doeswijk2
1European Alliance for Personalised Medicine, The Hague, The Netherlands.
Abstract:
Who would have thought that in the most recent decade of the 21st century, shortages of medicines would be on the rise? As the authors will show, it is not simply about price, but involves other factors such as sudden outbreaks of a disease or diseases, a lack of raw materials, manufacturing issues and high demand. Shortages of medicines can lead to higher costs and lower quality and safety of care, while unavailable medicines tend to be substituted with often less effective medicines, which can even be more costly. Possible solutions involve a monitoring of supply chains and "early warning" systems as well as Member States getting together to purchase medicines as a group. There is no single answer, and there is much work to be done.
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