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Phage display as a tool for vaccine and immunotherapy development
Krystina L Hess1, Christopher M Jewell2,3,4,5,6
1U.S. Army Combat Capabilities Development Command Chemical Biological Center Aberdeen Proving Ground Maryland.
Bioengineering & Translational Medicine
|January 29, 2020
Summary
Bacteriophages (phages) are viruses used in bioengineering for vaccines. They display antigens effectively, activating immune responses for infectious disease and cancer vaccination.
Area of Science:
- Biotechnology
- Immunology
- Virology
Background:
- Bacteriophages (phages) are viruses that infect bacteria, with applications in bioengineering.
- Phages activate innate and adaptive immune systems, making them valuable for vaccines and immunotherapies.
- Phage genomes and surface proteins can be engineered for antigen delivery.
Purpose of the Study:
- To review the use of bacteriophages as antigen delivery vehicles.
- To highlight phage adjuvanting activity in vaccination strategies.
- To discuss phage applications against infectious diseases and cancer.
Main Methods:
- Review of existing literature on bacteriophage applications in immunology.
- Analysis of phage genome engineering for antigen display.
- Examination of phage surface protein modification for immune stimulation.
Main Results:
- Phages can be engineered to display specific antigens via capsid protein fusion.
- Phages possess inherent adjuvanting properties that enhance immune responses.
- Repetitive and ordered antigen presentation by phages improves immunogenicity.
Conclusions:
- Bacteriophages serve as effective antigen delivery vehicles for vaccine development.
- Phage-based vaccines show potential for combating infectious diseases and cancer.
- Further research into phage adjuvanting activity can optimize vaccine design.
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