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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

3.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.3K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Related Experiment Video

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Generation of Human 3D Lung Tissue Cultures 3D-LTCs for Disease Modeling
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Lung functional development and asthma trajectories.

Fabienne Decrue1, Olga Gorlanova1, Jakob Usemann1,2

  • 1University Children's Hospital (UKBB), University of Basel, Spitalstrasse 33, 4056, Basel, Switzerland.

Seminars in Immunopathology
|January 29, 2020
PubMed
Summary
This summary is machine-generated.

Early life exposures like pollution and infections impact lung development, potentially causing chronic respiratory diseases later in life. Interventions can modify these lung growth trajectories for better long-term health.

Keywords:
AsthmaChildrenDevelopmentEnvironmental factorLung growthReview

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Area of Science:

  • Respiratory Medicine
  • Environmental Health
  • Pediatrics

Background:

  • Early life environmental exposures are linked to chronic respiratory diseases in children and adults.
  • Lung development during early life is a critical period of plasticity, influencing long-term respiratory health.

Purpose of the Study:

  • To review hereditary and environmental factors affecting early lung functional development.
  • To understand the mechanisms linking early life influences to impaired lung function and future respiratory morbidity.

Main Methods:

  • Systematic review of evidence on ante-, peri-, and early postnatal factors.
  • Analysis of factors including air pollution, tobacco, nutrition, prematurity, infections, microbiome, and allergies.
  • Examination of inflammatory processes mediating environmental impacts.

Main Results:

  • Various factors (e.g., prematurity, infections, pollution) impair lung growth and development.
  • Environmental influences often act through inflammation and oxidative stress.
  • Impaired lung growth can lead to reduced maximal lung capacity and increased risk of asthma and COPD.

Conclusions:

  • Early life factors significantly shape lung functional trajectories, impacting adult respiratory health.
  • Preventive strategies targeting early life exposures are crucial for mitigating chronic respiratory diseases.
  • Further research and prevention programs are needed to address abnormal lung development.