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Advances in colon-targeted nano-drug delivery systems: challenges and solutions

Muhammad Naeem1,2, Uzma Azeem Awan1, Fazli Subhan1

  • 1Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Punjab, Pakistan.

Archives of Pharmacal Research
|January 29, 2020
PubMed

Insights

Nano-drug delivery systems (NDDS) offer targeted colon delivery for diseases like ulcerative colitis and colon cancer. Advances in NDDS aim to overcome challenges for efficient, localized treatment with reduced systemic toxicity.

Area of Science:

  • Nanomedicine
  • Gastroenterology
  • Drug Delivery

Background:

  • Nano-drug delivery systems (NDDS) are crucial for treating colon-specific diseases like ulcerative colitis, Crohn's disease, and colon cancer.
  • Targeted delivery enhances therapeutic efficacy and reduces systemic toxicity by concentrating treatments in diseased colon areas.
  • Challenges include premature drug release, degradation in the stomach, pH variations, mucus entrapment, and upper intestinal uptake.

Purpose of the Study:

  • To review potential applications of colon-specific drug delivery systems.
  • To identify and discuss challenges associated with orally administered colon-targeted delivery systems.
  • To summarize recent advancements and future prospects in orally administered NDDS for colon targeting.

Main Methods:

  • Literature review of scientific publications on colon-targeted nano-drug delivery.
  • Analysis of challenges and recent advancements in NDDS for oral administration.
  • Synthesis of information on the development and future of colon-specific drug delivery.

Main Results:

  • NDDS show promise for localized treatment of colon diseases, improving drug efficacy and reducing side effects.
  • Significant hurdles remain, including physiological barriers in the gastrointestinal tract that can compromise delivery.
  • Recent innovations are emerging to address these challenges, paving the way for more effective colon-targeted therapies.

Conclusions:

  • Despite challenges, advancements in NDDS offer significant potential for improved colon-specific drug delivery.
  • Overcoming barriers like degradation and premature release is key to successful therapeutic outcomes.
  • Continued research into NDDS is vital for developing efficient treatments for colon disorders.
Keywords:
Colon-targetingColorectal cancerNano-drug deliveryUlcerative colitis

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