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Published on: January 7, 2019
OMEGA-3 Interventions in Alcohol Dependence and Related Outcomes: A Systematic Review and Propositions
José Carlos F Galduróz1, Andréia Gomes Bezerra1, Gabriel Natan Pires1,2
1Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Background:
Pharmacological treatment for alcohol dependence has only three approved drugs: disulfiram, naltrexone and acamprosate. The effects of these drugs are, however, limited, presenting several side effects and a modestly higher efficacy compared to placebo. The administration of omega-3 might bring new perspectives to relapse prevention.
Methods:
This systematic review aimed to analyze the available literature, compiling the studies that used omega-3 to prevent relapse in alcohol dependents.
Results:
The databases used were PubMed and Web of Science. We identified 2,231 studies and only five articles addressed the administration of omega-3 and alcoholism. Preclinical studies evaluating the effects of PUFAs related to chronic alcohol administration showed improvements in behavioral, cellular and molecular levels. The clinical trial yielded inconclusive results.
Conclusion:
Despite the reduced number of studies, omega-3 interventions seem to be promising for controlling issues related to alcohol dependence.
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