Related Experiment Video

Updated: Dec 29, 2025

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

11.0K

Challenges in the Discovery of Novel Therapeutic Agents in Cancer

Ganji Purnachandra Nagaraju1, Mohammad Amjad Kamal2,3,4

  • 1Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States.

Current Drug Metabolism
|January 29, 2020
PubMed

Insights

Developing novel cancer therapies is crucial to overcome drug resistance and improve patient survival. New treatments must enhance solubility, bioavailability, and target specificity for better outcomes in precision medicine.

Area of Science:

  • Oncology
  • Pharmacology
  • Cancer Biology

Background:

  • Cancer drug resistance, intrinsic or acquired, poses a significant therapeutic challenge, leading to treatment failure, metastasis, and mortality.
  • Complex signaling pathways and adaptive mechanisms drive treatment evasion under selective pressure.
  • There is a critical need for novel therapeutic compounds and regimens to combat resistance and improve survival rates.

Discussion:

  • New therapeutic agents must be designed to target specific alterations within the tumor microenvironment.
  • Enhanced solubility, tumor penetration, and bioavailability are essential properties for next-generation cancer drugs.
  • Improved target specificity is required to overcome resistance to traditional chemotherapies.

Key Insights:

  • Addressing drug resistance is paramount for advancing cancer treatment efficacy.
  • Novel therapeutic strategies must focus on overcoming the adaptive mechanisms of cancer cells.
  • Developing drugs with superior pharmacokinetic and pharmacodynamic properties is key.

Outlook:

  • The development of advanced therapeutic modalities will facilitate the realization of precision medicine.
  • Personalized therapeutic approaches tailored to individual patient profiles will improve cancer survival outcomes.
  • Continued research into overcoming drug resistance is vital for future cancer therapy innovations.
Keywords:
Cancerdrug analoguesdrug resistancegenetic manipulationsimmune systemstem cellstherapy.

More Related Videos

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.5K
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

9.0K

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.3K