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Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count

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Published on: July 11, 2012

Low-toxicity carbon quantum dots derived from gentamicin sulfate to combat antibiotic resistance and eradicate mature

Peili Li¹, Shuai Liu¹, Weiwei Cao¹

¹School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China. xingxiaodong07@njust.edu.cn.

Chemical Communications (Cambridge, England)

|January 29, 2020

Abstract:

Carbon quantum dots derived from gentamicin sulfate are directly developed by facile calcination at different temperatures. A promising nanomaterial, CQD180, even shows a much superior antibacterial activity compared with the antibiotic counterpart and low drug resistance, by preserving the active structure of the starting materials and providing an additional antibacterial mode arising from the positive charge surface and induced reactive oxygen species simultaneously. Moreover, CQD180 can effectively disrupt mature Staphylococcus aureus biofilm and selectively eliminate bacteria over mammalian cells.

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