A Method for the Preparation of β-Amino-α,β-unsaturated Carbonyl Compounds: Study of Solvent Effect and Mechanism
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Updated: Dec 29, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Reyno R S1, Akash Sugunan1, Ranganayakulu S1
1School of Chemistry , Indian Institute of Science Education and Research , Thiruvananthapuram , Kerala 695551 , India.
Abstract:
An efficient method for the preparation of β-amino-α,β-unsaturated carbonyl compounds is demonstrated. Bench-stable sodium 3-oxo-enolates were prepared from carbonyl compounds, and reacted with amines in the presence of an acid and a desiccant. DFT studies revealed contrasting mechanisms toward the reactivity of aliphatic amines in protic solvents and aromatic amines in aprotic solvents. While the former proceeds through the formation of an imine, the latter passes through the Michael addition-elimination mechanism.
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