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[Plasma viscosity and erythrocyte filterability in borderline hypertension]
B Bauduceau1, X Chanudet, R Clement
1Service de médecine interne et pathologie cardiovasculaire, HIA Bégin, Saint-Mande.
Journal Des Maladies Vasculaires
|January 1, 1988
Summary
In young men with borderline hypertension, red blood cell deformability increases with blood pressure. This contrasts with established hypertension, suggesting early adaptation before long-term changes occur.
Area of Science:
- Physiology
- Cardiovascular Science
- Hematology
Context:
- Investigating hemorheological factors in young males with borderline hypertension.
- Examining the relationship between blood pressure and erythrocyte properties.
Purpose:
- To analyze hemorheological constants, including plasma viscosity and erythrocyte filtrability index, in a cohort of young males.
- To determine if erythrocyte deformability correlates with systolic and diastolic blood pressure in borderline hypertension.
Summary:
- A study of 153 males (19-23 years) revealed no significant change in plasma viscosity.
- However, erythrocyte deformability showed a significant positive correlation with both systolic and diastolic blood pressure.
- This suggests an initial adaptive response of red blood cells to increased peripheral resistance in early hypertension.
Impact:
- Findings contrast with established hypertension, highlighting potential early adaptive mechanisms in red blood cells.
- Suggests that erythrocyte deformability may be an early indicator of cardiovascular stress.
- Provides insights into the long-term effects of hypertension on red blood cell membrane cytoskeleton.