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Stevens-Johnson syndrome and toxic epidermal necrolysis: a report of six cases

Ahu Kara1, İlker Devrim1, İlknur Çağlar1

  • 1Departments of Pediatric Infectious Diseases, Dr. Behçet Uz Children's Hospital, İzmir, Turkey.

The Turkish Journal of Pediatrics
|January 29, 2020
PubMed

Insights

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug reactions. Early ophthalmological evaluation is crucial for managing potential long-term ocular complications in SJS/TEN patients.

Area of Science:

  • Dermatology
  • Ophthalmology
  • Infectious Diseases

Background:

  • Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions (SCARs).
  • These conditions carry significant morbidity and mortality risks.
  • Triggers include medications and infections like Mycoplasma pneumoniae.

Observation:

  • This report details six cases of SJS or TEN with varied clinical presentations.
  • Patients received Intravenous Immunoglobulin (IVIG) and intensive supportive care for skin and mucosal lesions.
  • The median hospital stay was 13.5 days.

Findings:

  • Mycoplasma pneumoniae infection was identified as a potential trigger in some patients.
  • Ocular involvement was the most common long-term complication observed.
  • One patient developed corneal epithelial defects, highlighting the risk of eye complications.

Implications:

  • Ophthalmological assessment is essential at diagnosis and before hospital discharge for SJS/TEN patients.
  • Prompt eye evaluations can aid in early detection and management of ocular sequelae.
  • This underscores the multidisciplinary approach required for managing SCARs.

Keywords:
Stevens-Johnson syndromedrug reactionmycoplasma

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