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Complete atrioventricular block associated with clozapine intoxication: case report.

Mehmet Türe¹, Meki Bilici¹, Alper Akın¹

¹Division of Pediatric Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.

The Turkish Journal of Pediatrics

|January 29, 2020

Summary

Clozapine intoxication can cause complete atrioventricular block, a serious heart condition. This case report highlights the risk of this cardiac side effect in patients, even young ones.

Keywords:

clozapine complete atrioventricular block intoxication

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Area of Science:

Cardiology
Pharmacology
Toxicology

Background:

Clozapine is an atypical antipsychotic used for treatment-resistant schizophrenia.
Cardiac side effects of clozapine, though rare, include myocarditis, cardiomyopathy, hypotension, and QT prolongation.
Complete atrioventricular (AV) block is a critical condition where atrial signals cannot reach the ventricles.

Observation:

A 15-year-old female presented with complete AV block after a clozapine overdose.
The patient intentionally ingested a large dose of clozapine.

Findings:

Clozapine intoxication can induce complete AV block.
This effect may result from increased vagal tone and inhibition of cardiac node signaling.
The case demonstrates a severe, acute cardiac manifestation of clozapine toxicity.

Implications:

Clinicians should consider clozapine toxicity in cases of unexplained AV block.
Cardiac monitoring is crucial for patients with clozapine overdose.
Understanding clozapine's cardiotoxic potential aids in managing psychiatric emergencies.