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Routine disaccharidase testing: are we there yet?
Antone R Opekun1,2,3, Bruno P Chumpitazi2,3, Mustafa M Abdulsada1
1Department of Medicine.
Current Opinion in Gastroenterology
|January 29, 2020
Summary
Disaccharidase testing aids in diagnosing gastrointestinal issues like functional bowel disorders. While not routine, it can guide management for carbohydrate maldigestion and related symptoms.
Area of Science:
- Gastroenterology
- Digestive Health
- Clinical Diagnostics
Background:
- Disaccharidase testing is underutilized in diagnosing gastrointestinal disturbances.
- Carbohydrate maldigestion can impact functional bowel disorders and the gut microbiome.
Purpose of the Study:
- To evaluate the clinical utility of disaccharidase testing.
- To explore how disaccharidase test results can influence patient management.
Main Methods:
- Review of diagnostic techniques including enzyme assays, immunohistochemistry, breath testing, and genetic testing.
- Analysis of sucrase-isomaltase gene variants and deficiency prevalence.
Main Results:
- Disaccharidase deficiencies are more common than previously recognized.
- Testing plays a role in evaluating unexplained abdominal discomfort and symptoms.
Conclusions:
- Disaccharidase testing is valuable for symptom evaluation but faces accuracy and logistical challenges.
- Improved testing methods are needed to guide patient management, dietary changes, and enzyme supplementation.
