Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

465
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
465
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

201
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
201
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

3.9K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
3.9K
Pharmacodynamics: Overview and Principles01:21

Pharmacodynamics: Overview and Principles

2.7K
Pharmacodynamics is a scientific field that delves into drugs' intricate biochemical, cellular, and physiological effects on the human body. The study of pharmacodynamics helps us understand how drugs interact with the body and elicit various responses.
Most drugs' effects result from their interactions with drug receptors or targets within the body. These interactions trigger specific responses at the cellular or systemic level. Drug receptors can be found on the surfaces of cells or...
2.7K
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

15.8K
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
15.8K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

147
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
147

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Re-thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics.

British journal of pharmacology·2026
Same author

Mechanistic insights into atrazine-driven endothelial dysfunction: The contribution of endoplasmic reticulum stress.

Toxicology·2026
Same author

The effect of dehydroepiandrosterone on the vascular system: role of H<sub>2</sub>S/NO pathways.

European journal of pharmacology·2026
Same author

Role of cystathionine β-synthase in modulating NO and H₂S signaling under metabolic stress in obesity-driven endothelial dysfunction.

Life sciences·2026
Same author

Nutraceutical potential of radish (<i>Raphanus sativus</i> cv. Tango) microgreens as sustainable and reproducible sources of hydrogen sulfide-releasing compounds.

Food chemistry: X·2026
Same author

Hydrogen sulfide generated by cystathionine gamma lyase inhibits lysyl oxidase and protects against calcific tendinopathy.

Journal of orthopaedic translation·2026

Related Experiment Video

Updated: Dec 29, 2025

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

703

Pharmacology and perspectives in erectile dysfunction in man.

Emma Mitidieri1, Giuseppe Cirino1, Roberta d'Emmanuele di Villa Bianca1

  • 1Department of Pharmacy, School of Medicine and Surgery, University of Naples, Federico II, Via D. Montesano, 49, 80131 Naples, Italy.

Pharmacology & Therapeutics
|January 29, 2020
PubMed
Summary

Erectile dysfunction (ED) involves complex neurovascular processes. This review covers ED mechanisms, treatments like PDE5 inhibitors, and future therapies for the 30% of men who don't respond to current options.

Keywords:
Erectile dysfunctionErectile functionHuman corpus cavernosumPeripheral mechanismsRisk factors, cardiovascular disease

More Related Videos

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
08:03

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents

Published on: June 6, 2018

14.9K
Intracavernous Pressure Recording in a Cavernous Nerve Injury Rat Model
05:48

Intracavernous Pressure Recording in a Cavernous Nerve Injury Rat Model

Published on: September 20, 2021

1.9K

Related Experiment Videos

Last Updated: Dec 29, 2025

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

703
Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
08:03

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents

Published on: June 6, 2018

14.9K
Intracavernous Pressure Recording in a Cavernous Nerve Injury Rat Model
05:48

Intracavernous Pressure Recording in a Cavernous Nerve Injury Rat Model

Published on: September 20, 2021

1.9K

Area of Science:

  • Urology
  • Andrology
  • Reproductive Medicine

Background:

  • Penile erection is a complex neurovascular process involving psychological, hormonal, and vascular systems.
  • Erectile dysfunction (ED) is the inability to attain or maintain sufficient penile erection for sexual activity.
  • The advent of phosphodiesterase-5 (PDE5) inhibitors significantly advanced ED research.

Purpose of the Study:

  • To review the peripheral mechanisms and mediators of penile function in men.
  • To discuss current therapeutic drugs for ED.
  • To explore future prospects in ED management, addressing unmet needs.

Main Methods:

  • Literature review of preclinical and clinical studies on penile erection and ED.
  • Analysis of the role of vascular endothelium, smooth muscle, and neuro-hormonal systems.
  • Examination of the efficacy and limitations of existing ED therapies, including PDE5 inhibitors.

Main Results:

  • Detailed overview of mediators and peripheral mechanisms regulating penile erection.
  • Discussion of pharmacological treatments, highlighting the limitations of PDE5 inhibitors for some patients.
  • Identification of a significant unmet need, with 30% of ED patients classified as non-responders.

Conclusions:

  • Understanding the intricate mechanisms of penile erection is crucial for managing ED.
  • Current therapies, while effective for many, leave a substantial portion of patients with unresolved issues.
  • Further research is needed to develop novel therapeutic alternatives for non-responder ED patients.