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Can ethanol affect the cell structure? A dynamic molecular and Raman spectroscopy study.

Luis Felipe C S Carvalho1, Laurita Dos Santos2, Franck Bonnier3

  • 1FOCAS Research Institute, Technological University Dublin, Kevin Street, Dublin 8, Ireland; Universidade de Taubate, Taubaté, Brazil; Centro Universitário Braz Cubas, Mogi das Cruzes, SP, Brazil.

Photodiagnosis and Photodynamic Therapy
|January 29, 2020
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Summary

Ethanol directly impacts oral cells by altering cell membrane lipids, potentially increasing permeability. This suggests alcohol consumption alone may contribute to oral cancer development.

Keywords:
CarcinogenesisDynamic molecular modellingEthanolLipidsOral cancerRaman spectroscopy

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Cancer Research

Background:

  • Tobacco and alcohol are established risk factors for oral cancer.
  • The independent role of alcohol in oral carcinogenesis is increasingly recognized.
  • Some oral cancer patients exhibit only alcohol consumption or no identifiable risk factors.

Purpose of the Study:

  • To investigate the direct effects of ethanol on oral cells in vitro.
  • To elucidate the molecular mechanisms by which alcohol may contribute to oral cancer.

Main Methods:

  • Dynamic molecular modeling was employed to simulate ethanol-cell interactions.
  • Raman spectroscopy was utilized to analyze structural changes in oral cells upon ethanol exposure.

Main Results:

  • Ethanol was observed to interact significantly with lipids in the cell membrane.
  • These interactions led to conformational changes in the cell membrane lipids.
  • Evidence suggests ethanol alters cell membrane permeability.

Conclusions:

  • Ethanol's interaction with oral cell membranes can affect cell permeability.
  • This alteration in permeability positions ethanol as a potential independent trigger for oral carcinogenesis.