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Multiple metal exposure and platelet counts during pregnancy: A repeated measure study
Shuangshuang Bao1, Wei Xia1, Shunqing Xu1
1Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
This study found that pregnant women exposed to higher levels of cadmium, manganese, and arsenic had lower platelet counts. Cadmium exposure was particularly linked to an increased risk of gestational thrombocytopenia.
Area of Science:
- Environmental Health
- Hematology
- Reproductive Health
Background:
- Limited human data exists on the association between metal exposure and platelet counts (PLT) in pregnant women.
- Animal and in vitro studies suggest metals can interfere with normal PLT levels.
Purpose of the Study:
- To investigate the associations between repeated measures of 13 urinary metals and PLT during pregnancy.
- To assess the risk of gestational thrombocytopenia associated with metal exposure.
Main Methods:
- A prospective cohort study of 3911 pregnant women in Wuhan, China (2013-2016).
- Measurement of 13 urinary metals and blood PLT across three trimesters.
- Analysis using mixed linear models, general linear models, and generalized estimating equations.
Main Results:
- Decreased PLT levels were associated with increased urinary concentrations of cadmium (Cd), manganese (Mn), and arsenic (As).
- Cd showed an inverse association with PLT throughout pregnancy.
- Cd exposure increased the odds of gestational thrombocytopenia in all three trimesters.
Conclusions:
- Cd, Mn, and As are associated with reduced PLT during pregnancy.
- Cd exposure may elevate the risk of developing gestational thrombocytopenia.
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