Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Survival Tree01:19

Survival Tree

339
Survival trees are a non-parametric method used in survival analysis to model the relationship between a set of covariates and the time until an event of interest occurs, often referred to as the "time-to-event" or "survival time." This method is particularly useful when dealing with censored data, where the event has not occurred for some individuals by the end of the study period, or when the exact time of the event is unknown.
 Building a Survival Tree
Constructing a...
339
Phylogenetic Trees03:21

Phylogenetic Trees

49.1K
Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
49.1K
Light Acquisition02:16

Light Acquisition

9.3K
In order to produce glucose, plants need to capture sufficient light energy. Many modern plants have evolved leaves specialized for light acquisition. Leaves can be only millimeters in width or tens of meters wide, depending on the environment. Due to competition for sunlight, evolution has driven the evolution of increasingly larger leaves and taller plants, to avoid shading by their neighbors with contaminant elaboration of root architecture and mechanisms to transport water and nutrients.
9.3K
Inductive Reasoning00:59

Inductive Reasoning

64.4K
Inductive reasoning is a form of logical thinking that uses related observations to arrive at a general conclusion. It is uncertain and operates in degrees to which the conclusions are credible. As such, inductive arguments can be weak or strong, rather than valid or invalid, and conclusions can be used to formulate testable, falsifiable hypotheses.
Inductive reasoning is common in descriptive science. A life scientist makes observations and records them. This data can be qualitative or...
64.4K
Drug Discovery: Overview01:26

Drug Discovery: Overview

10.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.8K
Woodward–Hoffmann Selection Rules and Microscopic Reversibility01:34

Woodward–Hoffmann Selection Rules and Microscopic Reversibility

3.7K
Electrocyclic reactions, cycloadditions, and sigmatropic rearrangements are concerted pericyclic reactions that proceed via a cyclic transition state. These reactions are stereospecific and regioselective. The stereochemistry of the products depends on the symmetry characteristics of the interacting orbitals and the reaction conditions. Accordingly, pericyclic reactions are classified as either symmetry-allowed or symmetry-forbidden. Woodward and Hoffmann presented the selection criteria for...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Exploratory Analysis of Predictors of Concordance between Canadian Common Drug Review Reimbursement Recommendations and the Subsequent Decisions by Ontario, British Columbia and Alberta.

Healthcare policy = Politiques de sante·2020
Same author

Untargeted Contrast-Enhanced Ultrasound Versus Contrast-Enhanced Computed Tomography: A Differential Diagnostic Performance (DDP) Study for Kidney Lesions.

Clinics (Sao Paulo, Brazil)·2020
Same author

Long-term prognostic value of stress myocardial perfusion echocardiography in patients with coronary artery disease: a meta-analysis.

European heart journal. Cardiovascular Imaging·2020
Same author

Is the whole larger than the sum of its parts? Impact of missing data imputation in economic evaluation conducted alongside randomized controlled trials.

The European journal of health economics : HEPAC : health economics in prevention and care·2020
Same author

Iridium/Acid Cocatalyzed Direct Access to Fused Indoles via Transfer Hydrogenative Annulation of Quinolines and 1,2-Diketones.

Organic letters·2020
Same author

The effect of TLR4 on the growth and local inflammatory microenvironment of HPV-related cervical cancer in vivo.

Infectious agents and cancer·2020
Same journal

Exploiting audio-visual modalities in videos: Object detection via multi-stage bilateral coupling network.

Neural networks : the official journal of the International Neural Network Society·2026
Same journal

Reliability-aware modality completion with cross-modal distillation for federated learning with missing modalities.

Neural networks : the official journal of the International Neural Network Society·2026
Same journal

IGFD-Net: Illumination-guided frequency decoupling for polarization image fusion.

Neural networks : the official journal of the International Neural Network Society·2026
Same journal

Multiple-Strategies dung beetle optimizer and its applications in engineering optimization and bankruptcy prediction.

Neural networks : the official journal of the International Neural Network Society·2026
Same journal

Aggregating global-scale pixel-wise forgery cues within a graph.

Neural networks : the official journal of the International Neural Network Society·2026
Same journal

Finite-Time intermittent control for secure synchronization of Neutral-Type stochastic delayed neural networks under aperiodic DoS attacks.

Neural networks : the official journal of the International Neural Network Society·2026
See all related articles

Related Experiment Video

Updated: Dec 29, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.8K

A causal discovery algorithm based on the prior selection of leaf nodes.

Yan Zeng1, Zhifeng Hao2, Ruichu Cai1

  • 1School of Computer Science, Guangdong University of Technology, Guangzhou, China.

Neural Networks : the Official Journal of the International Neural Network Society
|January 29, 2020
PubMed
Summary
This summary is machine-generated.

The new GPL algorithm improves causal network discovery by prioritizing leaf nodes, reducing computational complexity and enhancing accuracy for high-dimensional or small-sample data. This approach offers a more efficient method for causal discovery compared to traditional root-node focused models.

Keywords:
Causal discoveryCausal orderLeaf nodesLinear Non-Gaussian Acyclic Models

More Related Videos

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

8.3K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K

Related Experiment Videos

Last Updated: Dec 29, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.8K
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

8.3K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K

Area of Science:

  • Causal inference and network analysis
  • Machine learning and artificial intelligence

Background:

  • Linear Non-Gaussian Acyclic Models (LiNGAM) are prevalent for causal network discovery.
  • Existing LiNGAM methods face computational complexity and accuracy issues with high-dimensional data or small sample sizes, often due to root node selection.
  • These limitations hinder effective causal discovery in complex datasets.

Purpose of the Study:

  • To propose a novel causal discovery algorithm, the GPL (Giving Priority to Leaf-nodes) algorithm.
  • To address the computational and accuracy limitations of existing LiNGAM methods.
  • To provide a more efficient and accurate approach for causal network discovery, particularly for challenging data conditions.

Main Methods:

  • Introduced the GPL algorithm, which prioritizes leaf nodes instead of root nodes for causal ordering estimation.
  • Leveraged the property that leaf nodes do not influence other nodes to enable direct, bottom-up causal ordering estimation.
  • Developed theoretical proofs for the algorithm's feasibility and superiority based on leaf node characteristics.

Main Results:

  • The GPL algorithm demonstrated superior performance over state-of-the-art methods in both computational complexity and accuracy.
  • Experimental results on synthetic and real-world data confirmed GPL's effectiveness, especially for high-dimensional data (up to 200 variables) and small sample sizes (down to 100 samples for 70 dimensions).
  • GPL avoids complex data updating processes inherent in root-node prioritized methods.

Conclusions:

  • The GPL algorithm offers a significant advancement in causal discovery, overcoming key limitations of traditional LiNGAM approaches.
  • Its leaf-node prioritization strategy provides a more computationally efficient and accurate method for inferring causal networks.
  • GPL is particularly advantageous for analyzing complex, high-dimensional datasets with limited sample sizes.