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Published on: August 28, 2019
Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology
Wei Hou1, Bo Liu2, Hongtao Xu3
1College of Pharmaceutical Science and Institute of Drug Development & Chemical Biology (IDD & CB), Zhejiang University of Technology, Hangzhou, China.
Abstract:
Celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has gained extensive exploration due to its unique structure features and multiple promising biological activities. This review will focus on the structural modifications, structure-activity relationships, pharmacology, and toxicology of celastrol in the past ten years. We hope this review would be helpful to get a better grasp of the progresses in the field and provide constructive suggestions for the further study of celastrol.
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