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Updated: Dec 29, 2025
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Published on: September 30, 2021
Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside
Gabriel Siracusano1, Mariella Tagliamonte2, Luigi Buonaguro2
1Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milan, Italy.
Abstract:
Cell surface proteins act as the go-between in carrying the information from the extracellular environment to the intracellular signaling proteins. However, these proteins are often deregulated in neoplastic diseases, including hepatocellular carcinoma. This review discusses several recent studies that have investigated the role of cell surface proteins in the occurrence and progression of HCC, highlighting the possibility to use them as biomarkers of the disease and/or targets for vaccines and therapeutics.
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