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Anti-Fungal Efficacy and Mechanisms of Flavonoids

Mohammed Saleh Al Aboody1, Suresh Mickymaray1

  • 1Department of Biology, College of Science, Al-Zulfi, Majmaah University, Riyadh region, Majmaah 11952, Saudi Arabia.

Antibiotics (Basel, Switzerland)
|January 30, 2020
PubMed

Insights

Naturally occurring flavonoids show promise as antifungal agents, potentially overcoming drug resistance and reducing toxicity when used with conventional medicines. This review explores their antifungal activities and synergistic potential.

Area of Science:

  • Mycology and Pharmacology
  • Natural Product Chemistry

Background:

  • Rising prevalence of fungal infections and challenges in understanding pathogenesis.
  • Antifungal resistance and the urgent need for novel therapeutic agents.
  • Flavonoids, a class of plant-derived compounds, exhibit potential health benefits.

Purpose of the Study:

  • To review naturally occurring flavonoids with antifungal activities.
  • To explore their mechanisms of action against fungal pathogens.
  • To assess their synergistic potential with conventional antifungal drugs.

Main Methods:

  • Literature review of scientific studies on flavonoids and antifungal properties.
  • Analysis of reported antifungal activities, modes of action, and combination therapies.
  • Synthesis of information on naturally occurring flavonoids with clinical relevance.

Main Results:

  • Flavonoids demonstrate significant antifungal activity at low concentrations.
  • Synergistic combinations of flavonoids with existing drugs can enhance efficacy.
  • Flavonoids offer a potential strategy to combat antifungal resistance and reduce drug toxicity.

Conclusions:

  • Naturally occurring flavonoids represent a promising source for developing new antifungal strategies.
  • Combining flavonoids with conventional drugs is a viable approach to improve treatment outcomes.
  • Further research into flavonoid-antifungal interactions is warranted for clinical application.
Keywords:
antifungal activityflavonoidsfungal diseasesmode of action

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