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Updated: Dec 29, 2025

The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy
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Acute Fatty Liver of Pregnancy: Rare, but Potentially Fatal

Andreia de Vasconcelos Gaspar1, Tânia C Ascensão1, Isabel Santos Silva1

  • 1Obstetrics Service B, Bissaya Barreto Maternity, Coimbra University and Hospital Center, Coimbra, Portugal.

The American Journal of Case Reports
|January 30, 2020
PubMed

BACKGROUND Acute fatty liver of pregnancy is an obstetric emergency characterized by liver dysfunction, which can lead to severe maternal and fetal complications. CASE REPORT A 34-year-old woman, 37 weeks and 2 days pregnant, reported symptoms of nausea, vomiting, jaundice, and prostration. Laboratory findings revealed liver dysfunction and coagulopathy. A clinical diagnosis of acute fatty liver was made and an emergency cesarean section was performed. The postoperative period was complicated by disseminated intravascular coagulation, acute hepatic and renal insufficiency, and pancreatitis. CONCLUSIONS Early recognition of this pathology, the interruption of pregnancy, and intensive therapy led to a favorable outcome.

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