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Human Genetic Susceptibility of Leprosy Recurrence
Priscila Verchai Uaska Sartori1, Gerson O Penna2,3,4, Samira Bührer-Sékula5
1Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Rua Imaculada Conceição 1155 - Prado Velho, Curitiba, Paraná, Brazil.
Scientific Reports
|January 30, 2020
Summary
Genetic factors may predispose individuals to leprosy recurrence. This study found an enrichment of risk alleles in recurrent leprosy cases, suggesting a genetic susceptibility profile for disease reoccurrence.
Area of Science:
- Genetics
- Infectious Diseases
- Immunology
Background:
- Host genetic susceptibility to leprosy is well-studied, but its role in disease recurrence remains unexplored.
- Previous findings indicated M. leprae strains in recurrent cases lacked known resistance mutations, suggesting host susceptibility.
- Whole genome sequencing confirmed identical M. leprae strains in two of three recurrent cases, pointing to host factors.
Purpose of the Study:
- To investigate the association between genetic variants and leprosy disease recurrence.
- To determine if individuals with recurrent leprosy possess a distinct genetic susceptibility profile.
- To identify specific genetic markers predisposing to leprosy relapse or reinfection.
Main Methods:
- Genotyping of 19 genetic markers across 11 loci (14 genes) classically associated with leprosy.
- Comparison of allele frequencies between leprosy patients with recurrent disease and matched non-recurrent cases.
- Analysis of genetic data to identify risk alleles associated with disease recurrence.
Main Results:
- An enrichment of specific risk alleles was observed in patients experiencing leprosy recurrence.
- The findings suggest a genetic predisposition to M. leprae infection and subsequent disease.
- A distinct genetic susceptibility profile may increase the risk of leprosy recurrence.
Conclusions:
- Host genetic factors play a significant role in leprosy disease recurrence.
- Identifying individuals with high genetic susceptibility could inform personalized prevention and treatment strategies.
- Further research into genetic predisposition is crucial for understanding and managing leprosy recurrence.
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