Core-shell gold-nickel nanostructures as highly selective and stable nonenzymatic glucose sensor for fermentation...

Area of Science:

• Electrochemistry
• Nanomaterials Science
• Biosensors

Background:

• Noble metal-based non-enzymatic electrodes offer high selectivity and sensitivity for glucose detection.
• However, traditional sensors are often susceptible to pH, temperature, and chemical interference.
• Developing robust and interference-resistant glucose sensors remains a significant challenge.

Purpose of the Study:

• To synthesize and characterize spherical gold-nickel core-shell nanoparticles (Au@Ni) for enhanced non-enzymatic glucose detection.
• To evaluate the performance of Au@Ni nanoparticles as a glucose sensor, focusing on selectivity, sensitivity, stability, and resistance to poisoning.
• To demonstrate the potential of Au@Ni nanoparticles in overcoming limitations of existing glucose sensing technologies.

Main Methods:

• Spherical gold-nickel core-shell nanoparticles (Au@Ni) were synthesized using oleylamine reduction of metal precursors.
• Electrochemical performance of the Au@Ni nanoparticles was evaluated for glucose oxidation.
• Key sensor parameters including operating voltage, linear range, response time, sensitivity, and detection limit were determined.

Main Results:

• The Au@Ni core-shell nanoparticles exhibited excellent electrocatalytic activity for glucose oxidation at a low operating voltage (0.10 V vs. SCE).
• The sensor demonstrated a wide linear detection range (0.5–10 mmol L^-1), rapid response time (approx. 3 s), and high sensitivity (23.17 μA cm^-2 mM^-1).
• The Au@Ni sensor showed remarkable tolerance to chlorine ions (Cl^-) and poisoning intermediates, maintaining stability and anti-toxicity.

Conclusions:

• The developed Au@Ni core-shell nanoparticles provide a promising platform for highly selective and sensitive non-enzymatic glucose detection.
• The sensor's robustness against common interferents and poisoning significantly enhances its practical applicability in complex biological samples.
• This core-shell nanostructure design offers a viable strategy for improving the performance and reliability of electrochemical biosensors.