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Metabo groups in response to micronutrient intervention: Pilot study.

Carolina Almeida Coelho-Landell1, Roberta Garcia Salomão1, Maria Olimpia Ribeiro do Vale Almada1

  • 1Department of Pediatrics and Department of Health Sciences Faculty of Medicine of Ribeirão Preto University of São Paulo São Paulo Brazil.

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Micronutrient supplementation impacted lipid profiles and protein expression in children and adolescents. Vitamin E and Native American ancestry influenced LDL cholesterol levels and responses to intervention.

Keywords:
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Area of Science:

  • Biochemistry and Molecular Biology
  • Nutritional Science
  • Genetics

Background:

  • Micronutrients are essential cofactors in lipid metabolism.
  • Understanding micronutrient roles in lipid profiles is crucial for metabolic health.
  • Genetic factors can influence nutrient metabolism and response to supplementation.

Purpose of the Study:

  • To investigate the effects of multivitamin and mineral supplementation on lipid metabolism in children and adolescents.
  • To explore the relationship between genetic ancestry, micronutrient levels, and lipid profiles.
  • To analyze proteomic changes in response to micronutrient intervention.

Main Methods:

  • A subproject of the Harmonized Micronutrient Project involving 20 children and adolescents.
  • Randomized selection and division into two pools based on baseline lipid profiles.
  • Analysis of anthropometric, body composition, dietary intake, lipid profiles, micronutrient levels, and iTRAQ proteomic data at baseline, post-supplementation, and post-washout.
  • Determination of genetic ancestry and its association with vitamin serum levels.

Main Results:

  • Supplementation decreased LDL levels and increased alpha-tocopherol and pantothenic acid in one pool (Pool 2).
  • Lipid profiles in Pool 1 remained stable but showed higher baseline levels of certain B vitamins.
  • Proteomic analysis revealed differential protein expression changes in response to supplementation, varying between pools.
  • Plasma alpha-tocopherol and Native American genetic ancestry were significant predictors of LDL levels and intervention response.

Conclusions:

  • Micronutrient supplementation can modulate lipid profiles and protein expression in a subset of children and adolescents.
  • Vitamin E and Native American genetic ancestry play a role in regulating LDL cholesterol and response to vitamin E intervention.
  • Further validation in larger cohorts or in vitro studies is warranted to confirm these pilot findings.