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Increased QT Interval Dispersion is Associated with Coronary Artery Involvement in Children with 
Kawasaki Disease

Ehsan Aghaei Moghadam1,2, Leila Hamzehlou2, Bobak Moazzami2

  • 1Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.

Oman Medical Journal
|January 30, 2020
PubMed

Insights

QT dispersion is elevated in children with Kawasaki disease (KD) who have coronary artery involvement. This finding may help predict cardiac complications in KD patients.

Area of Science:

  • Pediatric Cardiology
  • Rheumatology
  • Electrophysiology

Background:

  • Kawasaki disease (KD) is a significant cause of acquired heart disease in children, with coronary artery (CA) involvement being a primary concern.
  • QT dispersion, a measure of repolarization heterogeneity, has shown potential in predicting cardiac events like ischemia and arrhythmias.
  • Limited research exists on the utility of QT dispersion in assessing cardiac involvement in KD patients.

Purpose of the Study:

  • To investigate the relationship between QT dispersion and coronary artery involvement in pediatric patients diagnosed with Kawasaki disease.
  • To determine if QT dispersion can serve as a biomarker for cardiac complications in KD.

Main Methods:

  • A cross-sectional study was conducted involving 70 consecutive patients diagnosed with KD according to American Heart Association guidelines.
  • Data collected included demographics, clinical features, laboratory results, and echocardiographic findings.
  • QT dispersion was measured from 12-lead ECGs during the acute phase of KD.

Main Results:

  • A total of 70 KD patients (43 males, 27 females) were analyzed, with a median age of 21 months.
  • Statistically significant differences in age, gender, and platelet count were observed between patients with and without CA involvement (p < 0.050).
  • Median corrected QT dispersion was significantly higher in patients with CA involvement (108.0 ms) compared to those without (63.0 ms) (p < 0.001).

Conclusions:

  • Prolonged QT dispersion, both corrected and non-corrected, during acute and convalescent phases is associated with coronary artery involvement in Kawasaki disease.
  • QT dispersion may be a valuable non-invasive marker for identifying KD patients at higher risk for cardiac complications.
Abstract

Keywords:
AneurysmElectrocardiographyKawasaki Disease

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